Lentiviral Vectors

Overview

This guideline describes biosafety considerations and best practices for conducting a pathogen risk assessment or local risk assessment for a containment zone where lentiviral vectors are handled or stored, so that appropriate mitigation measures may be implemented. The guideline presents risk factors and risk mitigation strategies to be considered when performing risk assessments and when establishing biosafety procedures.

Who this guide is for

• Pathogen and Toxin Licence holders
• Biological Safety Officers
• Personnel in regulated facilities

In this guide

• Preface
• Abbreviations and acronyms
• Chapter 1  Introduction
  • 1.1 Scope
  • 1.2 How to use the Lentiviral vectors guideline
• Chapter 2  Description of lentiviral vectors
  • 2.1 Retroviruses
  • 2.2 Evolution of retroviral vector systems
• Chapter 3  Risk assessment
  • 3.1 Pathogen risk assessment
  • 3.2 Local risk assessment
• Chapter 4  Considerations for containment
  • 4.1 Containment level requirements
  • 4.2 Work practices
  • 4.3 Animal work considerations
  • 4.4 Post-exposure prophylaxis
  • 4.5 Decontamination and waste management
• Chapter 5  Glossary
• Chapter 6  References and resources

View complete guide
Download PDF (2.41 MB, 48 pages)

Details and history

Published: September 5, 2019

For assistance

Contact the Public Health Agency of Canada (PHAC) if you need assistance:
By phone: 1-613-957-1779
By e-mail: pathogens.pathogenes@phac-aspc.gc.ca
The PHAC's service hours are Monday to Friday from 8 am to 4 pm (eastern time). They are closed on statutory holidays.

Contact us by mail:

100 Colonnade Road
Ottawa, Ontario
K1A 0K9

Service standards: 

We respond to mail and email within two business days. If we can't answer your question right away, we will send you an estimated date.