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Tobacco and Stomach Cancer

Cigarettes cause stomach cancer.Footnote 1Footnote 2Footnote 3

Key facts about tobacco use and stomach cancer

  • Someone who smokes is more likely to develop stomach cancer than someone who does not smoke.Footnote 4
  • The risk of stomach cancer increases with the number of years smoked, the number of cigarettes smoked per day, and the age at smoking initiation.Footnote 1Footnote 4
  • Approximately 20% of stomach cancer cases were due to smoking in 2015.Footnote 3
  • In 2021, it was estimated there would be 4,000 new cases of stomach cancer in Canada, and 1,950 stomach cancer deaths.Footnote 5
  • In Canada, 71% of people diagnosed with stomach cancer are predicted to die within five years, according to 2015-2017 data.Footnote 5

View health-related messages for all tobacco product packaging.

What is stomach cancer?

Stomach or gastric cancer is the uncontrolled growth of abnormal cells in the stomach lining, leading to the formation of a tumour.

The stomach lining is made of five layers. Stomach cancer starts in the inner layer of the stomach called the mucosa and can spread to outer layers as the cancer grows. Once the cancer spreads through all the layers of the stomach and to other organs, the chances of recovery decrease.Footnote 6

Early symptoms of stomach cancer include abdominal pain, bloating, nausea, and vomiting. In more advanced stages of stomach cancer, symptoms include vomiting blood, blood in the stool, and unexplained weight loss.Footnote 7

Treatments for stomach cancer include surgery to remove part or all of the stomach, radiation, or chemotherapy, depending on the severity and location of the cancer.Footnote 6

How does tobacco use increase the risk of stomach cancer?

Some of the chemicals in tobacco smoke can cause genetic changes in the cells of the stomach lining. This can lead to the development of stomach cancer.Footnote 1

Tobacco smoke and nicotine can play a role in the formation of ulcers (open sores) that damage the stomach lining.Footnote 1 Ulcers increase the risk of genetic changes in the cells, which can cause stomach cancer.Footnote 8 The seriousness of stomach ulcers depends on the amount of cigarettes smoked.Footnote 1

How does quitting reduce the risk of stomach cancer?

Quitting smoking reduces the risk of stomach cancer.Footnote 9Footnote 10 This risk decreases with the number of years since quitting.Footnote 2 Ten years after quitting, the risk of stomach cancer is similar to someone who has never smoked.Footnote 2

Quitting is one of the best ways to avoid the development of stomach cancer and other tobacco-related diseases.Footnote 9

If someone who smokes has stomach cancer, quitting can improve their chances of recovery.Footnote 11

Continuing to smoke after a cancer diagnosis can lower chances of survival and increase the risk for second primary cancers caused by tobacco smoke, such as lung cancer.Footnote 11

Health benefits of quitting tobacco use at any age

Quitting tobacco use reduces the risk of premature death, improves health, and enhances quality of life.Footnote 9 Quitting at any age is beneficial to one's health.Footnote 9 Even people who have smoked or used tobacco heavily for many years benefit from it.Footnote 1Footnote 9 Quitting is the most important thing someone who smokes can do to improve their health.

Read more about the benefits of quitting smoking.

Call for free help to quit

Call the toll-free pan-Canadian quit line at 1-866-366-3667. Quit line counselling, alone or in combination with cessation medication, increases success in quitting.Footnote 9

Footnotes

Footnote 1

U.S. Department of Health and Human Services. The Health Consequences of Smoking. A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2004.

Return to footnote 1 referrer

Footnote 2

Praud D, Rota M, Pelucchi C, Bertuccio P, Rosso T, Galeone C, Zhang ZF et al. Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project. Eur J Cancer Prev. 2018 Mar;27(2):124-133. doi: 10.1097/CEJ.0000000000000290. PMID: 27560662.

Return to footnote 2 referrer

Footnote 3

Poirier AE, Ruan Y, Grevers X, Walter SD, Villeneuve PJ, Friedenreich CM, Brenner DR; ComPARe Study Team. Estimates of the current and future burden of cancer attributable to active and passive tobacco smoking in Canada. Prev Med. 2019 May;122:9-19. doi: 10.1016/j.ypmed.2019.03.015. PMID: 31078177.

Return to footnote 3 referrer

Footnote 4

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Tobacco Smoke and Involuntary Smoking. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 83. International Agency of Research on Cancer, Lyon, France, 2004.

Return to footnote 4 referrer

Footnote 5

Canadian Cancer Statistics Advisory Committee. Canadian Cancer Statistics 2021. Toronto, ON: Canadian Cancer Society: 2021. http://cancer.ca/Canadian-Cancer-Statistics-2021-EN

Return to footnote 5 referrer

Footnote 6

PDQ Adult Treatment Editorial Board. Gastric Cancer Treatment (PDQ®): Patient Version. Bethesda, MD: National Cancer Institute (US); 2002 https://www.ncbi.nlm.nih.gov/books/NBK65889/

Return to footnote 6 referrer

Footnote 7

Smyth EC, Nilsson M, Grabsch HI, van Grieken NC, Lordick F. Gastric cancer. The Lancet. 2020 Aug 29;396(10251):635-48.

Return to footnote 7 referrer

Footnote 8

Li LF, Chan RL, Lu L, Shen J, Zhang L, Wu WK, Wang L, Hu T, Li MX, Cho CH. Cigarette smoking and gastrointestinal diseases: the causal relationship and underlying molecular mechanisms. International journal of molecular medicine. 2014 Aug 1;34(2):372-80.

Return to footnote 8 referrer

Footnote 9

U.S. Department of Health and Human Services. Smoking Cessation: A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2020.

Return to footnote 9 referrer

Footnote 10

Gandini S, Botteri E, Iodice S, Boniol M, Lowenfels AB, Maisonneuve P, Boyle P. Tobacco smoking and cancer: a meta-analysis. Int J Cancer. 2008 Jan 1;122(1):155-64. doi: 10.1002/ijc.23033. PMID: 17893872.

Return to footnote 10 referrer

Footnote 11

U.S. Department of Health and Human Services. The Health Consequences of Smoking: 50 Years of Progress. A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2014.

Return to footnote 11 referrer

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2023-07-26

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