Proposed Registration Decision PRD2026-02, Isocycloseram, A21377 CP, A21708 CP, A22466 CP, EQUENTO RFC and A23294 TO

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• Pest Management Regulatory Agency
• 29 January 2026
• ISSN: 1925-0886 (PDF version)
• Catalogue number: H113-9/2026-2E-PDF (PDF version)

Summary

Table of contents

• Proposed registration decision for Isocycloseram
• What does Health Canada consider when making a registration decision?
• What is isocycloseram?
• Health considerations
• Environmental considerations
• Value considerations
• Measures to minimize risk
• Next steps
• Other information

Proposed registration decision for Isocycloseram

Health Canada's Pest Management Regulatory Agency (PMRA), pursuant to subsection 28(1) of the Pest Control Products Act, is proposing registration for the sale and use of Isocycloseram Technical, A21377 CP, A21708 CP, A22466 CP, EQUENTO RFC and A23294 TO, containing the active ingredient isocycloseram. A21377 CP and A21708 CP are for the control of various insect and mite pests by foliar application on a broad range of field vegetables, fruit and nut trees, soybean, and peanut (and corn for A21708 CP). A22466 CP is for in-furrow application to control corn rootworms and wireworms in corn (field, seed and pop). EQUENTO RFC is a seed treatment product for the control of wireworms in dry lentils. A23294 TO, also containing the active ingredient chlorantraniliprole, is for the control or suppression of various pests in greenhouse ornamentals and turf.

Isocycloseram is currently registered for the control of cockroaches in commercial, industrial and residential buildings and other listed structures, and as a seed treatment product for the control of insect pests and for the control or suppression of seed-borne and soil-borne diseases on wheat, oat, barley, rye and triticale. For details, see Proposed Registration Decision PRD2025-11, Isocycloseram, VANECTO COCKROACH GEL BAIT, EQUENTO and A23128 ST, and Registration Decision RD2026-03, Isocycloseram, VANECTO COCKROACH GEL BAIT, EQUENTO and A23128 ST.

In the end-use product A23294 TO, isocycloseram is co-formulated with chlorantraniliprole. Chlorantraniliprole is currently registered to control a variety of insect pests in several agricultural crops, ornamentals and turf, to control subterranean termites in various sites, and as a seed treatment product on corn, cereals and dry legume vegetables to control or suppress various pests. For details, see Proposed Registration Decision PRD2016-08, Chlorantraniliprole, Registration Decision RD2016-17, Chlorantraniliprole, Proposed Registration Decision PRD2013-08, Chlorantraniliprole, Registration Decision RD2014-26, Chlorantraniliprole, Proposed Registration Decision PRD2010-27, Chlorantraniliprole, Registration Decision RD2011-02, Chlorantraniliprole, and ERC2008-03, Chlorantraniliprole.

An evaluation of available scientific information found that, under the approved conditions of use, the health and environmental risks and the value of the pest control products are acceptable.

This summary (Proposed Registration Decision PRD2026-02, Isocycloseram, A21377 CP, A21708 CP, A22466 CP, EQUENTO RFC and A23294 TO) describes the key points of the evaluation, while the Science evaluation of the full version of PRD2026-02 provides detailed technical information on the human health, environmental and value assessments of isocycloseram, A21377 CP, A21708 CP, A22466 CP, EQUENTO RFC and A23294 TO.

What does Health Canada consider when making a registration decision?

The primary objective of the Pest Control Products Act is to prevent unacceptable risks to individuals and the environment from the use of pest control products. Health or environmental risk is considered acceptable^{Footnote 1} if there is reasonable certainty that no harm to human health, future generations or the environment will result from use or exposure to the product under its proposed conditions of registration. The Act also requires that products have value^{Footnote 2} when used according to the label directions. Conditions of registration may include precautionary measures on the product label to further reduce risk.

To reach its decisions, Health Canada's PMRA applies modern, rigorous risk-assessment methods and policies. These methods consider the unique characteristics of sensitive subpopulations in humans (for example, children). They also consider the unique characteristics of organisms in the environment. These methods and policies also consider the nature of the effects observed and the uncertainties when predicting the impact of pesticides. For more information on how Health Canada's PMRA regulates pesticides, the assessment process and risk-reduction programs, please visit the Pesticides and pest management portion of Canada.ca.

Before making a final registration decision on isocycloseram, A21377 CP, A21708 CP, A22466 CP, EQUENTO RFC and A23294 TO, Health Canada's PMRA will consider any written comments received from the public directly related to the proposed decision in PRD2026-02.^{Footnote 3} Health Canada will then publish a Registration Decision^{Footnote 4} on isocycloseram, A21377 CP, A21708 CP, A22466 CP, EQUENTO RFC and A23294 TO, which will include the decision, the reasons for it, a summary of comments received on the proposed registration decision and Health Canada's response to these comments.

For more details on the information presented in this summary, please refer to the Science evaluation of PRD2026-02.

What is isocycloseram?

Isocycloseram is a new conventional chemical insecticide that targets the nervous system of insects and mites on contact and through ingestion. It is effective against agricultural pests when applied as a seed treatment, a foliar spray to plants or as an in-furrow treatment at planting.

Health considerations

Can approved uses of isocycloseram affect human health?

Products containing isocycloseram are unlikely to affect your health when used according to proposed label directions.

Potential exposure to isocycloseram may occur through the diet (food and drinking water), when handling and applying the end-use products, or when coming into contact with treated surfaces. When assessing health risks, two key factors are considered:

• the levels at which no health effects occur and
• the levels to which people may be exposed.

The dose levels used to assess risks are selected to protect the most sensitive human population (for example, children and nursing mothers). As such, sex and gender are taken into account in the risk assessment. Only uses for which the exposure is well below levels that cause no effects in animal testing are considered acceptable for registration.

Toxicology studies in laboratory animals describe potential health effects from varying levels of exposure to a chemical and identify the dose level at which no effects are observed. The health effects noted in animals occur at dose levels more than 100-times higher (and often much higher) than levels to which humans are normally exposed when pesticide products are used according to label directions.

In laboratory animals, the technical grade active ingredient, Isocycloseram Technical, was of low acute toxicity by the oral, dermal and inhalation routes of exposure. Isocycloseram was non-irritating to the eyes and skin but caused an allergic skin reaction. Consequently, the hazard statement "POTENTIAL SKIN SENSITIZER" is required on the label.

The end-use product, A21377 CP, containing isocycloseram, was of low acute toxicity by the oral, dermal and inhalation routes of exposure. It was non-irritating to the eyes and skin and did not cause an allergic skin reaction.

The end-use product, A21708 CP, containing isocycloseram, was of low acute toxicity by the oral and inhalation routes of exposure. It was also classified as being of low acute toxicity by the dermal route of exposure. It was non-irritating to the skin, but was mildly irritating to the eyes and caused an allergic skin reaction. Consequently, the signal word and hazard statements "CAUTION – EYE IRRITANT" and "POTENTIAL SKIN SENSITIZER" are required on the label.

The end-use product, A22466 CP, containing isocycloseram, was of low acute toxicity by the oral and inhalation routes of exposure. It was also classified as being of low acute toxicity by the dermal route of exposure. It was non-irritating to the skin, but was corrosive to the eyes and caused an allergic skin reaction. Consequently, the signal word and hazard statements "DANGER – CORROSIVE TO EYES" and "POTENTIAL SKIN SENSITIZER" are required on the label.

The end-use product, EQUENTO RFC, containing isocycloseram, was of low acute toxicity by the oral and inhalation routes of exposure. It was also classified as being of low acute toxicity by the dermal route of exposure. It was minimally irritating to the eyes and skin and did not cause an allergic skin reaction.

The end-use product, A23294 TO, containing isocycloseram and chlorantraniliprole, was of low acute toxicity by the oral and inhalation routes of exposure. It was also classified as being of low acute toxicity by the dermal route of exposure. It was minimally irritating to the eyes, non-irritating to the skin and did not cause an allergic skin reaction.

Prior to the initial registration of isocycloseram, registrant-supplied short- and long-term (lifetime) animal toxicity tests, as well as information from the published scientific literature, were assessed for the potential of isocycloseram to cause neurotoxicity, immunotoxicity, chronic toxicity, cancer, reproductive and developmental toxicity, and various other potential human health hazards. The most sensitive endpoints for risk assessment were effects on body weight, altered fetal development, and reduced survival of the young. There was no evidence to suggest that isocycloseram damaged genetic material. An increase in ovarian tumours in female mice and testicular tumours in male rats could not clearly be attributed to treatment with isocycloseram. There was an indication that the young were more sensitive than the adult animal. The risk assessment protects against the effects noted above and other potential effects by ensuring that the level of exposure to humans is well below the lowest dose level at which these effects occurred in animal tests.

Occupational risks from handling A21377 CP, A21708 CP, A22466 CP, and A23294 TO

Occupational risks are not of health concern when A21377 CP, A21708 CP, A22466 CP, and A23294 TO are used according to the proposed label directions, which include protective measures.

Workers mixing, loading or applying A21377 CP, A21708 CP, A22466 CP, and A23294 TO, and workers entering treated fields and greenhouses can be exposed to isocycloseram residues through direct skin contact or through inhalation. For A21377 CP, A21708 CP, A22466 CP and A23294 TO, the label specifies that workers must wear a long-sleeved shirt, long pants, chemical-resistant gloves, socks and shoes during mixing, loading, application, clean-up and repair. In addition, for handheld application of A21377 CP, A21708 CP and A23294 TO, workers should wear eye, head and respiratory protection when applying above waist height, including overhead. For A21708 CP, the label also requires that workers wear protective eyewear (goggles or face shield) during open-cab airblast application. For A22466 CP, workers must also wear protective eyewear (goggles or face shield) during mixing, loading, clean-up and repair.

For A21377 CP, A21708 CP, and A22466 CP, the label requires that workers not enter or be allowed entry into treated fields during the restricted-entry interval (REI) of 12 hours. For A23294 TO, the label requires that workers not enter or be allowed entry into treated golf courses until sprays have dried. For sod farms and ornamentals grown in greenhouses, workers must not enter or be allowed entry during the REI of 12 hours.

Taking into consideration the label statements, the number of applications and the duration of exposure for handlers and postapplication workers, the risks to these individuals from exposure to A21377 CP, A21708 CP, A22466 CP, and A23294 TO are not of health concern when the end-use products are used according to the proposed label directions.

Occupational risks from handling EQUENTO RFC

Occupational risks are not of health concern when EQUENTO RFC is used according to the proposed label directions, which include protective measures.

Workers in commercial facilities (and mobile treaters) mixing, loading, calibrating equipment and treating lentil seeds, and those involved in bagging, sewing and stacking bags of treated seed, cleaning and repair and driving a forklift, can come in direct contact with isocycloseram residues on the skin and through inhalation. Therefore, these workers must wear the personal protective equipment and comply with the engineering controls specified in Appendix I, Table 1 of PRD2026-02.

Farmers treating and planting lentil seeds and farmers planting commercially treated lentil seeds may also come in direct contact with isocycloseram through direct skin contact or inhalation. Therefore, farmers must also wear the personal protective equipment and comply with the engineering controls specified in Appendix I, Table 1 of PRD2026-02. In addition, for good hygiene practice, it is recommended that workers wear a NIOSH-approved N95 filtering facepiece respirator (dust mask) that is properly fit tested during all activities.

Taking into consideration the label statements and the durations of exposure for all workers, the risks to these individuals from exposure to EQUENTO RFC are not of health concern when the end-use product is used according to the proposed label directions.

Health risks in residential and other non-occupational environments

Risks in residential and other non-occupational environments are not of health concern when A21377 CP, A21708 CP, A22466 CP, EQUENTO RFC, and A23294 TO are used according to the proposed label directions and REIs are observed.

A21377 CP and A21708 CP

A21377 CP and A21708 CP are not domestic class products; therefore, residential applicator risk assessments were not required. However, these end-use products are permitted for use on orchard crops (pome fruits, stone fruits, and tree nuts) which may be grown in residential areas. Adults and children can come into direct contact with isocycloseram when orchard trees on pick-your-own farms or residential properties are treated with A21377 CP and A21708 CP. Taking into consideration the label statements, the number of applications and the duration of exposure, the risks to individuals contacting treated trees are not of health concern when the end-use products are used according to the label directions.

A22466 CP and EQUENTO RFC

A22466 CP and EQUENTO RFC are not domestic class products, nor is residential exposure expected. Therefore, risks in residential and other non-occupational environments are not of health concern when used according to the proposed label directions.

A23294 TO

A23294 TO is not a domestic class product; however, it is proposed for use on turf in residential areas and on golf courses. Adults, youths and children golfing, and adults and youth participating in high contact activities on treated turf can come into direct contact with isocycloseram residues. Therefore, the label requires that individuals do not enter treated golf courses until sprays have dried. In addition, the label requires that for residential areas, individuals should not enter or be allowed to enter treated areas until sprays have dried. Taking into consideration the label statements, the number of applications and the duration of exposure, the risks to individuals golfing and contacting treated turf are not of health concern when used according to the proposed label directions.

Health risks to bystanders

Bystander risks are not of health concern when A21377 CP, A21708 CP, A22466 CP, EQUENTO RFC, and A23294 TO are used according to the proposed label directions and spray drift restrictions are observed.

Standard label statements to protect against drift during application are on the labels. Therefore, health risks to bystanders are not of concern when the end-use products are used according to the proposed label directions.

Residue in food and drinking water

Dietary risks from food and drinking water are not of health concern.

Aggregate acute dietary (food plus drinking water) intake estimates did not exceed 65% of the acute reference dose (ARfD) when head lettuce was removed from the dietary risk assessments for all population subgroups, including females 13–49 years. Initial aggregate acute dietary (food plus drinking water) intake estimates indicated that females 13–49 years are exposed to 115% of the acute reference dose (ARfD), and therefore are of health concern. As the risks are driven by the dietary contribution of head lettuce, the use of isocycloseram on head lettuce is not supported.

Aggregate chronic dietary (food (except head lettuce) plus drinking water) intake estimates indicated that the general population and all population subgroups are exposed to less than 22% of the acceptable daily intake, and therefore are not of health concern.

On the strength of the overall information, it was determined that a threshold approach was appropriate for the cancer risk assessment based on the observed tumours. Overall, the endpoints selected for the chronic dietary risk assessment are considered protective of the findings, including potential cancer effects.

The Food and Drugs Act prohibits the sale of adulterated food, that is, food containing a pesticide residue that exceeds the established maximum residue limit (MRL). Pesticide MRLs are established for Food and Drugs Act purposes through the evaluation of scientific data under the Pest Control Products Act. Given that dietary risks from the consumption of foods are shown to be acceptable when isocycloseram is used according to the supported label directions, which excludes head lettuce, MRLs are being proposed as a result of this assessment (refer to PMRL2026-03, Isocycloseram).

MRLs for isocycloseram determined from the acceptable residue trials conducted throughout Canada and the United States, including growing regions representative of Canada, in or on potatoes, leaf lettuce, spinach, mustard greens, cabbage, broccoli, cauliflower, tomatoes, bell peppers, non-bell peppers, eggplants, cucumbers, melons, squash, apples, pears, peaches, plums, cherries, almonds, pecans, field corn, popcorn, peanuts, dry beans, dry peas and dry soybeans can be found in the Science evaluation of this document.

Aggregate health risks from dietary and residential exposures

Aggregate risks to adults, youth and children from dermal contact to and consumption of isocycloseram residues are not of health concern when A21377 CP, A21708 CP, and A23294 TO are used according to the proposed label directions.

A21377 CP, A21708 CP, and A23294 TO

Adults and children can come into direct contact with isocycloseram residues when orchard trees on residential properties are treated with A21377 CP and A21708 CP. For A23294 TO, adults, youth and children can come into direct contact with isocycloseram residues during golfing and high contact lawn activities. Chronic dietary exposure to isocycloseram from food and drinking water must also be considered in the determination of aggregate risks. In turn, the aggregate risks to adults and children from dermal and dietary exposure are not of health concern when the end-use products are used according to the label directions.

Environmental considerations

What happens when isocycloseram is introduced into the environment?

When isocycloseram is used according to the label directions, the risks to the environment are acceptable for use as a foliar spray, in-furrow application, seed treatment and use in greenhouses.

Isocycloseram enters the environment when it is applied as a foliar spray, an in-furrow application and as a seed treatment. Limited environmental exposure is expected when isocycloseram is used in greenhouses. Isocycloseram may remain in soil for long periods of time. Isocycloseram has limited ability to move downward in the soil. As it may remain in the soil for long periods of time, isocycloseram may reach groundwater. Isocycloseram has the potential to run off into aquatic habitats. In water, isocycloseram is expected to move to sediment, where it remains for short to long periods of time depending on the type of water/sediment system and environmental conditions. Isocycloseram is not expected to build-up in the tissues of plants or animals. However, when used in accordance with the label directions, including all the required risk mitigation measures, the use is acceptable as a foliar spray outdoors and in greenhouses, as an in-furrow application and as a seed treatment application.

Value considerations

What is the value of A21377 CP, A21708 CP and A23294 TO?

The foliar application products A21377 CP and A21708 CP provide a new mode of action for use against insect and mite pests on a broad range of agricultural food crops.

The foliar application product A23294 TO provides a new mode of action against various insect and mite pests on a broad range of greenhouse ornamental crops and turf.

A21377 CP and A21708 CP provide control of various economically important pests on a broad range of field vegetables, fruit and nut trees, corn, soybean and peanut. Isocycloseram is a new active ingredient with a new mode of action for use against various pests (Appendix I, Tables 41–44 of PRD2026-02), which will help manage resistance to the registered alternative pest control products. For a few of the pests, there are no other pest control products registered.

A23294 TO provides control of various economically important pests in greenhouse ornamental crops and turf. A23294 TO contains both isocycloseram and chlorantraniliprole, with isocycloseram providing a new mode of action for use against various pests of greenhouse ornamental crops and turf.

What is the value of EQUENTO RFC?

The seed treatment product EQUENTO RFC provides a new mode of action for control of wireworms in dry lentils.

Wireworms can reduce lentil plant stands and under high pest pressure can cause large economic damage to dry lentil crops. EQUENTO RFC will provide a new mode of action (IRAC Group 30 insecticide) for control of wireworm in lentils.

What is the value of A22466 CP?

The soil-applied pesticide A22466 CP provides a new active ingredient for control of corn rootworms and wireworms in corn.

Corn rootworms and wireworms can reduce plant stand of corn crops and under high pest pressure can cause large economic loss to corn crops. As a new active ingredient, A22466 CP will aid in resistance management of these pests in corn.

Measures to minimize risk

Labels of registered pesticide products include specific instructions for use. Directions include risk-reduction measures to protect human health and the environment. These directions must be followed by law.

The key risk-reduction measures being proposed on the labels of Isocycloseram Technical, A21377 CP, A21708 CP, A22466 CP, EQUENTO RFC and A23294 TO to address the potential risks identified in this assessment are as follows.

Key risk-reduction measures - Human health

A21377 CP and A21708 CP

To reduce a risk of concern identified during the review, the use of isocycloseram on head lettuce is not supported. This was based on the risks of concern identified for females 13–49 years of age, driven by the dietary contribution of head lettuce. A risk-based MRL of 0.01 ppm (analytical method limit of quantitation) is proposed.

A21377 CP, A21708 CP, A22466 CP, and A23294 TO

To reduce the potential exposure of workers to isocycloseram through direct skin contact or inhalation of sprays, workers mixing, loading and applying A21377 CP, A21708 CP, A22466 CP and A23294 TO, and performing cleaning and repair activities must wear a long-sleeved shirt, long pants, chemical-resistant gloves, socks and shoes. In addition, for handheld application of A21377 CP, A21708 CP, and A23294 TO, workers must wear eye, head and respiratory protection when applying above waist height, including overhead. For A21708 CP, workers must also wear protective eyewear (goggles or face shield) during open-cab airblast application. For A22466 CP, workers must wear protective eyewear (goggles or face shield) during mixing, loading, clean-up and repair. For A23294 TO, workers must not apply more than one single application at 1.11 L of product/ha per crop cycle for cut flowers grown in greenhouses.

For A21377 CP, A21708 CP, and A22466 CP, workers must not enter or be allowed entry into treated fields during the restricted-entry interval (REI) of 12 hours. For A23294 TO, workers must not enter or be allowed entry into treated golf courses until sprays have dried. For sod farms and ornamentals grown in greenhouses, workers must not enter or be allowed entry during the REI of 12 hours. Risks to workers are not of health concern when A21377 CP, A21708 CP, A22466 CP, and A23294 TO are used according to the proposed label directions and REIs are observed. Furthermore, a standard label statement to protect against drift during application is required.

EQUENTO RFC

To reduce the potential exposure of workers to isocycloseram through direct skin contact or inhalation of sprays, workers in commercial facilities (and mobile treaters) mixing, loading, calibrating equipment and treating lentil seeds, and those involved in bagging, sewing and stacking bags of treated seed, cleaning and repair and driving a forklift, must wear the personal protective equipment and comply with the engineering controls specified in Appendix I, Table 1 of PRD2026-02.

Farmers treating and planting lentil seeds and farmers planting commercially treated lentil seeds must also wear the personal protective equipment and comply with the engineering controls specified in Appendix I, Table 1 of PRD2026-02. In addition, for good hygiene practice, it is recommended that workers wear a NIOSH-approved N95 filtering facepiece respirator (dust mask) that is properly fit tested during all activities.

Risks to workers are not of health concern when EQUENTO RFC is used according to the proposed label directions. Furthermore, a standard label statement to protect against drift during application is present on the label.

Key risk-reduction measures - Environment

A21377 CP and A21708 CP

• Precautionary label statements indicating toxicity to beneficial arthropods, bees and aquatic organisms.
• Precautionary label statements to indicate leaching to groundwater is possible.
• Best management practice label statements to reduce runoff entering aquatic habitats.
• Mandatory construction and maintenance of a vegetative filter strip of at least 10 metres wide between the edge of the application area and adjacent, downhill aquatic habitats.
• Spray buffer zones for the protection of sensitive terrestrial and aquatic habitats.
• Statements indicating that the use of isocycloseram as a foliar spray is not compatible with integrated pest management programs that use beneficial arthropods.
• For crops that are moderately to highly attractive to bees, limiting application to evenings when bees are not actively foraging.

A22466 CP

• Precautionary label statements indicating toxicity to aquatic organisms.
• Precautionary label statements indicating toxicity to bees and also informing users that the product is not systemic and therefore minimal exposure or risk is expected.
• Precautionary label statements to indicate leaching to groundwater is possible.
• Best management practice label statements to reduce runoff entering aquatic habitats.
• Mandatory construction and maintenance of a vegetative filter strip of at least 10 metres wide between the edge of the application area and adjacent, downhill aquatic habitats.

A23294 TO

• Precautionary label statements indicating toxicity to aquatic organisms, bees and certain beneficial arthropods.
• Precautionary statements to indicate leaching to groundwater is possible.
• Best management practice label statements to reduce runoff entering aquatic habitats.
• Mandatory construction and maintenance of a vegetative filter strip of at least 10 metres wide between the edge of the application area and adjacent, downhill aquatic habitats.
• Spray buffer zones for the protection of sensitive terrestrial and aquatic habitats.
• Label statements indicating that the use of isocycloseram as a foliar spray on turf is not compatible with integrated pest management programs that use beneficial arthropods.
• Label statements for use on turf in lawns indicating that the product is toxic to bees and not to be applied if the treatment area contains plants or weeds that are blooming, and that if applications must be made to areas that contain plants or weeds that are blooming, restrict applications to the evening when most bees are not foraging.
• Label statements requiring applications be made in a way that does not allow the product to drift to blooming plants or weeds and to minimize spray drift to habitats close to the application site.
• For greenhouse uses: precautionary label statements indicating that applications of isocycloseram are to be avoided when bees and beneficial arthropods are in the treatment area.
• For greenhouse uses: label statement restricting the product to not be used on blooming greenhouse ornamentals if plants are to be moved outdoors while sprayed blooms remain on the plant.
• Label statements prohibiting releases, effluent or runoff from greenhouses.

EQUENTO RFC

• Precautionary label statements indicating toxicity to aquatic organisms, bees, birds and small wild mammals.
• Label statements indicating that any spilled or exposed seeds and dust must be incorporated into the soil or otherwise cleaned-up from the soil surface.
• Best management practice label statements to reduce runoff entering aquatic habitats.
• Best management practice label statements to minimize bee exposure to dust during planting of treated seed.
• Precautionary label statements to indicate leaching to groundwater is possible.

Next steps

Before making a final registration decision on isocycloseram, A21377 CP, A21708 CP, A22466 CP, EQUENTO RFC and A23294 TO, Health Canada's PMRA will consider any written comments received from the public that are directly related to PRD2026-02, such as comments directed to the Science evaluation, in response to PRD2026-02 up to 30 days from the date of publication (by 28 February 2026) of PRD2026-02. If more time is required to provide comments, a request for an extension of an additional 15 days can be made. Your request must be submitted in writing to the PMRA's Publications Section within the 30-day consultation period. Please note that, to comply with Canada's international trade obligations, consultation on the proposed MRLs will also be conducted internationally via a notification to the World Trade Organization.

Please forward all comments to PMRA Publications, through the Public Engagement Portal (Public Engagement Portal forms – Consultation Comment). Health Canada will then publish a Registration Decision, which will include its decision, the reasons for it, a summary of comments received on the proposed decision and Health Canada's response to these comments.

Other information

When Health Canada's PMRA makes its registration decision, it will publish a Registration Decision on isocycloseram, A21377 CP, A21708 CP, A22466 CP, EQUENTO RFC and A23294 TO (based on the Science evaluation of PRD2026-02). In addition, the test data referenced in this consultation document will be available for public inspection, upon application, in the PMRA's Reading Room. For more information or if you have questions, please contact the PMRA's Pest Management Information Service.